Description

Product Description: PT-141 (Bremelanotide)

Chemical Classification: Synthetic Melanocortin Receptor Agonist / Cyclic Heptapeptide

Research Overview

PT-141, chemically known as Bremelanotide, is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (-MSH). In molecular and neurochemical research, it is classified as a potent central melanocortin receptor agonist, demonstrating high binding affinity for the MC3R and MC4R subtypes. Derived from Melanotan II, PT-141 lacks the specific structural modification responsible for inducing melanogenesis (skin pigmentation), effectively isolating its physiological action to the central nervous system. It is a primary subject in studies exploring hypothalamic neurotransmission, neurobehavioral regulation, and non-vascular pathways involved in central physiological responses.

Common Research Applications

This central melanocortin agonist is frequently utilized in laboratory models to investigate the following experimental objectives:

  • Central Melanocortin Activation: Research focusing on selective ligand binding mechanics and intracellular signaling cascades of MC3R and MC4R within the medial preoptic area (mPOA) of the hypothalamus.
  • Neurobehavioral Modulation: Investigations into central mechanisms governing autonomic response and motivation without direct vascular smooth muscle mediation.
  • Dopaminergic & Oxytocinergic Crosstalk: Studies evaluating the downstream release of dopamine and oxytocin in central brain structures following melanocortin receptor stimulation.
  • Ischemia & Anti-Inflammatory Signaling: Research observing the cytoprotective and immunomodulatory properties mediated by peripheral and central melanocortin receptors in tissue damage models.
  • Energy Homeostasis: Exploration of MC4R-mediated signaling pathways in appetite regulation, energy expenditure, and metabolic homeostasis.

Laboratory Handling & Storage

  • Appearance: Lyophilized white powder.
  • Solubility: Highly soluble in water, sterile bacteriostatic water, or phosphate-buffered saline (PBS).
  • Stability: Highly stable in lyophilized form. Powder must be stored at -20°C for long-term preservation.  Protect from prolonged light exposure.