Description
ARA-290 (Cibinetide)
Chemical Classification: Erythropoietin (EPO) Derived Peptide
Research Overview
ARA-290 is a synthetic 11-amino acid peptide derived from the B-helix of erythropoietin (EPO). In molecular research, it is classified as a specific Innate Repair Receptor (IRR) ligand. Unlike full-chain EPO, ARA-290 does not bind to the homodimeric erythropoietin receptor responsible for red blood cell production (erythropoiesis). Instead, it selectively targets the heteromeric innate repair receptor (EPOR/CD131), making it a primary subject for studying tissue-protective signaling and neuropathic modulation without altering hematological parameters.
Common Research Applications
This non-erythropoietic peptide is frequently utilized in laboratory models to investigate the following experimental objectives:
- Neuropathic Pain Pathways: Studies focusing on the modulation of the TRPV1 channel and the reduction of pro-inflammatory cytokines within the peripheral nervous system.
- Small Fiber Neuropathy (SFN): Investigations into the peptide’s influence on the density of small nerve fibers and its role in promoting nerve fiber distal regeneration in in-vitro models.
- Anti-Inflammatory Cytokine Signaling: Research regarding the inhibition of TNF- and IL-6 production through the activation of innate repair mechanisms.
- Ischemia-Reperfusion Research: Studies exploring the cytoprotective effects of ARA-290 on organ tissue (kidney, heart, and pancreas) during simulated oxygen deprivation and subsequent reoxygenation.
- Metabolic Inflammation: Exploration of the peptide’s role in improving glucose homeostasis by modulating inflammation within pancreatic islet cells.
Laboratory Handling & Storage
- Appearance: Lyophilized white powder.
- Solubility: Highly water-soluble; easily reconstituted in sterile bacteriostatic water or phosphate-buffered saline (PBS).
- Stability: Highly stable in lyophilized form. Powder should be stored at -20°C for long-term preservation.