Description

Product Description: CJC-1295 with DAC

Chemical Classification: Long-Acting Growth Hormone-Releasing Hormone (GHRH) Analog / Bioconjugate Peptide

Research Overview

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic, bioconjugated 30-amino acid peptide analog of human Growth Hormone-Releasing Hormone (GHRH). In biochemical research, it is classified as an extended-duration somatotropic secretagogue. Through the incorporation of a maleimidopropionic acid (MPA) linker at the terminal lysine residue, CJC-1295 with DAC rapidly binds covalently to circulating serum albumin upon entry into biological media. This bioconjugation shields the peptide chain from rapid enzymatic degradation by dipeptidyl peptidase-4 (DPP-4) and prevents rapid renal clearance. As a result, its biological half-life is extended to approximately 6 to 8 days in research models, making it a primary subject for investigating sustained elevation of Growth Hormone (GH) and downstream Insulin-like Growth Factor 1 (IGF-1).

Common Research Applications

This bioconjugated GHRH analog is frequently utilized in laboratory models to investigate the following experimental objectives:

  • Albumin Bioconjugation Kinetics: Research focusing on the covalent binding mechanics between the maleimide reactive group and endogenous albumin to observe resistance against cleavage enzymes.
  • Sustained IGF-1 Induction: Investigations into multi-day hepatic secretion of IGF-1 following single-dose exposures, measuring prolonged protein synthesis and cellular accretion.
  • GHRH Receptor Desensitization Assays: Studies measuring anterior pituitary GHRH receptor sensitivity under continuous ligand exposure versus traditional pulsatile signaling.
  • Synergistic Secretagogue Assays: Research exploring the co-administration of CJC-1295 with DAC alongside ghrelin mimetics (such as Ipamorelin or GHRP-6) to evaluate combined baseline and peak GH release dynamics.
  • Metabolic & Lipid Mobilization: Exploration of prolonged growth hormone exposure on adipocyte lipolysis, nitrogen retention, and systemic energy metabolism in model systems.

Laboratory Handling & Storage

  • Appearance: Lyophilized white powder.
  • Purity: >98.0% (HPLC verified).
  • Solubility: Soluble in sterile bacteriostatic water for injection, or phosphate-buffered saline (PBS).
  • Stability: Highly stable in lyophilized form. Powder must be stored at -20°C for long-term preservation. Protect from direct light and avoid violent agitation to preserve the delicate bioconjugate structure.