Description

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c)

Chemical Classification: Mitochondrial-Derived Peptide (MDP)

Research Overview

MOTS-c is a 16-amino acid peptide encoded by the mitochondrial genome rather than the nuclear genome. In molecular biology, it is classified as a mitochondrial-derived peptide (MDP) that functions as a metabolic hormone. MOTS-c is a primary subject in studies exploring the retrograde signaling between mitochondria and the nucleus. It is investigated for its unique ability to translocate to the nucleus in response to metabolic stress, where it regulates gene expression to maintain cellular homeostasis and metabolic flexibility.

Common Research Applications

This mitochondrial-encoded peptide is frequently utilized in laboratory models to investigate the following experimental objectives:

  • AMPK Pathway Activation:Research focusing on the peptide’s ability to activate the AMP-activated protein kinase (AMPK) pathway, thereby increasing glucose uptake and fatty acid oxidation in skeletal muscle models.
  • Insulin Sensitivity Mechanisms:Investigations into the modulation of glucose metabolism and the peptide’s influence on insulin signaling pathways in various metabolic research subjects.
  • Mitochondrial Biogenesis:Studies regarding the regulation of mitochondrial DNA (mtDNA) transcription and the influence of MOTS-c on the density and efficiency of the mitochondrial network.
  • Osteoblast Signaling:Emerging research exploring the peptide’s role in bone metabolism, specifically its influence on the differentiation and mineralization of osteoblasts in in-vitro
  • Cellular Longevity & Proteostasis:Exploration of the “mitohormetic” response triggered by MOTS-c and its impact on the aging process and protein folding stability under physiological stress.

Laboratory Handling & Storage

  • Appearance:Lyophilized white powder.
  • Solubility:Soluble in water or bacteriostatic water; may require brief sonication or gentle agitation for complete dissolution at higher concentrations.

Stability: Stable at room temperature for short-term transit. For long-term preservation, lyophilized powder must be stored at -20°C.