Description

SNAP-8 (Acetyl Octapeptide-3)

Chemical Classification: Elongated Biomimetic Octapeptide

Research Overview

SNAP-8 (Acetyl Octapeptide-3) is a synthetic analog of the N-terminal end of the SNAP-25 protein. In molecular biology and dermatological research, it is classified as a neuro-modulatory peptide. It is specifically designed to investigate the inhibition of the SNARE (Soluble NSF Attachment Protein Receptor) complex. By mimicking a fragment of the SNAP-25 protein, this octapeptide is a primary subject in studies exploring the competitive inhibition of neurotransmitter release at the neuromuscular junction in in-vitro models.

Common Research Applications

This biomimetic octapeptide is frequently utilized in laboratory models to investigate the following experimental objectives:

  • SNARE Complex Destabilization:Research focusing on the peptide’s ability to compete with SNAP-25 for a position in the SNARE complex, thereby modulating the stability of the vesicular docking process.
  • Catecholamine Exocytosis:Investigations into the reduction of acetylcholine and glutamate release from neuronal cell cultures, specifically observing the “paralytic-mimetic” effects on muscle cell contraction models.
  • Dermal Topography Modulation:Studies regarding the influence of neurotransmission inhibition on the structural tension of epidermal layers and the subsequent impact on surface micro-relief.
  • Comparative Efficacy Studies:Research comparing the potency and receptor affinity of SNAP-8 against its predecessor, Acetyl Hexapeptide-8 (Argireline), in various synthetic skin models.
  • Signal Transduction Pathways:Exploration of the peptide’s role in altering the calcium-dependent fusion of vesicles with the cellular membrane.

Laboratory Handling & Storage

  • Appearance:Lyophilized white powder.
  • Solubility:Highly water-soluble; easily reconstituted in sterile water or buffered saline solutions.
  • Stability:Highly stable for a peptide of its size. Lyophilized powder should be stored at -20°C for long-term preservation. Once reconstituted, store at 2°C – 8°C