Description

Product Description: CJC-1295 (No DAC) & Ipamorelin Blend

Chemical Classification: Combined Somatotropic Secretagogue Solution (GHRH Analog + GHRP/Ghrelin Agonist)

Components: CJC-1295 (Mod GRF 1-29) / Ipamorelin

Research Overview

This dual-peptide combination pairs CJC-1295 (without Drug Affinity Complex) and Ipamorelin to investigate multi-receptor synergistic growth hormone secretagogue activity. In biochemical research, CJC-1295 acts as a tetrasubstituted analog of Growth Hormone-Releasing Hormone (GHRH), while Ipamorelin functions as a highly selective Growth Hormone Secretagogue Receptor (GHSR-1a) agonist. Co-administration of these two ligands allows researchers to examine the additive activation of distinct signaling pathways within the anterior pituitary gland, producing a magnified, natural pulsatile wave of Growth Hormone (GH) without elevating plasma cortisol, ACTH, or prolactin levels.

Common Research Applications

This synergistic formulation is frequently utilized in laboratory models to investigate the following experimental objectives:

Dual-Pathway Pituitary Synergism: Research evaluating the simultaneous stimulation of GHRH receptors and ghrelin receptors (GHSR-1a) to measure amplified somatotroph depolarization relative to single-agent exposure.

  • Pulsatile vs. Continuous GH Dynamics: Studies contrasting the physiological effects of short-acting, pulsatile secretagogue spikes (No DAC formulation) against long-acting, continuous baseline elevations.
  • IGF-1 Axis Modulation & Proteostasis: Investigations into downstream hepatic secretion of Insulin-like Growth Factor 1 (IGF-1) and its effects on protein synthesis, nitrogen retention, and cellular repair.
  • Selective Endocrine Profiling: Assays measuring growth hormone output while monitoring the absence of off-target stress-hormone releases (cortisol, aldosterone, and ACTH).
  • Adipose Tissue Lipolysis: Exploration of natural GH pulse spikes on adipocyte lipid breakdown, beta-oxidation rates, and systemic metabolic homeostasis.

Laboratory Handling & Storage

  • Appearance: Lyophilized white powder (Combined blend).
  • Solubility: Highly soluble in sterile bacteriostatic water or phosphate-buffered saline (PBS).
  • Stability: Highly stable in lyophilized form. Powder must be stored at -20°C for long-term preservation. Avoid intense physical agitation during reconstitution to maintain molecular integrity. Protect from direct exposure to light.