Description
Product Description: Ipamorelin
Chemical Classification: Growth Hormone Secretagogue (GHS) / Selective Ghrelin Receptor Agonist
Research Overview
Ipamorelin is a synthetic pentapeptide () recognized as one of the most selective growth hormone secretagogues in biochemical research. In molecular biology, it functions as a potent growth hormone secretagogue receptor (GHSR-1a) agonist, mimicking the physiological signaling of endogenous ghrelin. It is a primary subject in studies investigating the somatotropic axis because it stimulates the pulsatile release of Growth Hormone (GH) from the anterior pituitary gland without triggering a concurrent elevation in plasma cortisol, ACTH, or prolactin levels.
Common Research Applications
This selective pentapeptide is frequently utilized in laboratory models to investigate the following experimental objectives:
- Selective GH Pulsatility: Research focusing on the isolated secretion of Growth Hormone without non-target endocrine disruption, specifically observing the stability of ACTH and cortisol levels.
- Bone Mineral Density & Osteogenesis: Investigations into the stimulation of osteoblast activity and bone mineralization rates in longitudinal bone growth assays.
- Gastrointestinal Motility: Studies regarding the activation of peripheral ghrelin receptors to observe gastrointestinal transit times and postoperative ileus recovery models.
- Nitrogen Retention & Proteostasis: Research exploring the downstream effects of elevated GH and secondary IGF-1 on protein accretion and muscle tissue repair.
- Adipocyte Lipolysis: Exploration of the peptide’s indirect role in enhancing fatty acid oxidation and modulating energy expenditure in metabolic models.
Laboratory Handling & Storage
- Appearance: Lyophilized white powder.
- Solubility: Highly soluble in bacteriostatic water; reconstitution should be performed with gentle swirling to prevent structural degradation.
- Stability: Highly stable in lyophilized form.