Description

Selank

Chemical Classification: Synthetic Heptapeptide / Tuftsin Analog

Research Overview

Selank is a synthetic heptapeptide analog of the naturally occurring tetrapeptide Tuftsin. In molecular biology and neurochemical research, it is classified as a nootropic and anxiolytic peptide. It is a primary subject in studies exploring the modulation of the GABAergic system and the regulation of neurotransmitter balance within the central nervous system. Unlike traditional benzodiazepines, research on Selank focuses on its ability to stabilize emotional response and cognitive function without sedative-hypnotic side effects or the impairment of motor coordination in experimental models.

Common Research Applications

This neuro-modulatory heptapeptide is frequently utilized in laboratory models to investigate the following experimental objectives:

  • Neurotransmitter Regulation:Studies focusing on the peptide’s influence on the metabolism of serotonin (5-HT) and the concentration of norepinephrine and dopamine in the cerebral cortex.
  • GABA Receptor Affinity:Investigations into the allosteric modulation of  receptors and the subsequent impact on inhibitory neurotransmission.
  • Brain-Derived Neurotrophic Factor (BDNF):Research regarding the upregulation of BDNF mRNA expression in the hippocampus, exploring the peptide’s role in neuronal survival and synaptic plasticity.
  • Immunomodulatory Signaling:Studies exploring the interaction between the nervous and immune systems, specifically the peptide’s influence on interleukin-6 (IL-6) balance and cytokine expression during stress-induced states.
  • Enzymatic Degradation Inhibition:Research observing Selank’s ability to inhibit enkephalin-degrading enzymes, thereby potentially prolonging the activity of endogenous opioids (enkephalins) in the brain.

Laboratory Handling & Storage

  • Appearance:Lyophilized white powder.
  • Solubility:Highly water-soluble; easily reconstituted in sterile bacteriostatic water or phosphate-buffered saline (PBS).
  • Stability:Highly stable in lyophilized form. Powder should be stored at -20°C for long-term preservation.